The true story of an operation which was a revolution, not only for the world of medicine. Frankfurt 1967. A young doctor called Lisa Scheel is trying to get a foothold in the male-dominated world of transplant surgery. But after she is passed over by her main professor in favour of a male applicant, on the spur of the moment Lisa heads off to Cape Town. Here, she starts work for Dr. Barnaard, who, like his colleagues in Frankfurt, is planning a heart transplantation. Together with the surgeon Hamilton Naki, who due to apartheid can only join the team secretly, Lisa is a major contributor to the first heart transplant in history.